By all indications, Griffin, an outspoken critic of Trump, knew the images would be controversial.
"As it was put to us, "He's 11". Griffin has hosted alongside Anderson Cooper for the last decade; Cooper said Tuesday that he was "appalled" by the "clearly disgusting" photo.
Chelsea Clinton called the photo "vile and wrong", adding, "It is never amusing to joke about killing a president".
Trump weighed in Wednesday, calling her actions "sick".
It came after he broke his silence on the "covfefe" mystery that went viral on Wednesday and again accused Democrats of a "witch hunt" against his top aides over links to Russian Federation.
President Donald Trump responded Wednesday morning to comedienne Kathy Griffin's graphic and viral photo shoot this week that showed her holding up the Republican's bloody decapitated head, stating that his children are particularly disturbed by the fiasco, especially 11-year-old Barron.
First lady Melania Trump issued a statement of her own: "As a mother, a wife, and a human being, that photo is very disturbing".
In a video posted Tuesday night, Griffin said she was sorry.
Comedian Kathy Griffin has apologized and asked for the images of her posing with a model of President Trump's head covered in blood to be taken down by the photographer. "The image is too disturbing; I understand how it offends people. I beg for your forgiveness".
"I went too far", she says in a second video.
The photos - which were taken by photographer Tyler Shields - were released on Tuesday and immediately provoked condemnation and calls for a boycott of the comedian.
The caption is a reference to comments Trump made about journalist Megyn Kelly in 2015 after a fiery debate exchange.
Griffin was accused of encouraging violence against the President. Griffin has apologized, conceding that the brief video, which she originally described as an "artsy fartsy statement" mocking the commander in chief, was "too disturbing" and wasn't amusing.
Shields is well known for his envelope-pushing work. I understand how it offends people, it wasn't amusing.